En-clomiphene is the active trans-isomer of clomiphene citrate, is a nonsteroidal triphenylethylene derivative distantly related to diethylstilbestrol. It acts as a selective estrogen receptor modulator (SERM) that restarting the HPTA axis, the most common drug after the androgenic steroids cycle. its blocks the E2 receptors in the pituitary gland and in the body and boost the natural production of testosterone in the male.

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